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Updated: Nov 24, 2025

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
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Maternal morbidity after early preterm delivery (23-28 weeks).

Matthew P Romagano1, Onajovwe Fofah2, Joseph J Apuzzio1

  • 1Division of Maternal Fetal Medicine, Departments of Obstetrics, Gynecology, and Women's Health, Rutgers New Jersey Medical School, Newark, NJ.

American Journal of Obstetrics & Gynecology MFM
|December 21, 2020
PubMed
Summary
This summary is machine-generated.

Early preterm delivery before 26 weeks significantly increases maternal morbidity, including infection. Discussing these increased risks with expectant mothers is crucial for informed management of periviable births.

Keywords:
maternal morbidityperinatal infectionperiviable deliverypostpartum depressionpreterm birthpreterm deliverysevere maternal morbidity

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Perinatal Research

Background:

  • Maternal outcomes following preterm delivery are less understood compared to neonatal outcomes.
  • Previous research has primarily focused on neonatal complications of preterm and periviable births.

Purpose of the Study:

  • To investigate the association between early preterm delivery and increased maternal morbidity.
  • To compare maternal morbidity rates in deliveries before 26 weeks' gestation versus those between 26 and 28 weeks' gestation.

Main Methods:

  • Retrospective cohort study of 82 women delivering between 23 and 28 weeks' gestation.
  • Assessment of maternal morbidities including infection, hemorrhage, and postpartum depression.
  • Comparison of composite maternal morbidity between early (<26 weeks) and late (26-28 weeks) preterm delivery groups.

Main Results:

  • Women delivering before 26 weeks had significantly higher rates of composite maternal morbidity (60.5% vs 27.3%) and infection (42.1% vs 13.6%).
  • Later gestational age at delivery was associated with reduced rates of composite morbidity (OR 0.6).

Conclusions:

  • Delivery at periviable gestational ages is associated with elevated maternal morbidity.
  • Maternal complications, particularly infection, are more frequent in deliveries before 26 weeks' gestation.
  • Counseling for women at risk of early preterm birth should encompass potential maternal complications.