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Relationships between DNA repair and RTK-mediated signaling pathways
Thomas Chabot1, Yvonnick Cheraud1, Fabrice Fleury1
1Mechanism and regulation of DNA repair team, UFIP, CNRS UMR 6286, Université de Nantes, 2 rue de la Houssinière, 44322 Nantes, France.
Biochimica Et Biophysica Acta. Reviews on Cancer
|December 21, 2020
Summary
Receptor Tyrosine Kinases (RTKs) impact cancer cell survival and DNA repair. This review summarizes RTKs that modulate double-stranded DNA repair, suggesting new therapeutic strategies targeting RTK signaling and DNA repair pathways.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Receptor Tyrosine Kinases (RTKs) are crucial for cell signaling, proliferation, and survival.
- RTK dysregulation, including overexpression and hyperactivity, is common in cancer.
- Emerging research links RTK signaling to the modulation of DNA repair mechanisms.
Purpose of the Study:
- To review Receptor Tyrosine Kinases (RTKs) implicated in modulating double-stranded DNA repair pathways.
- To identify potential therapeutic targets by exploring the interplay between RTK signaling and DNA repair.
- To propose novel research directions for integrated cancer treatment strategies.
Main Methods:
- Literature review of scientific publications.
- Analysis of studies detailing RTK involvement in DNA repair pathways.
- Synthesis of findings on RTK-mediated modulation of double-stranded DNA repair.
Main Results:
- Identification of specific RTKs that act as potential modulators of double-stranded DNA repair.
- Evidence supporting a functional relationship between RTK signaling and DNA repair proteins.
- Highlighting the significance of RTK-DNA repair interactions in cancer pathology.
Conclusions:
- RTKs play a significant role in regulating DNA repair, particularly double-stranded breaks.
- Targeting RTK signaling alongside DNA repair pathways offers a promising avenue for cancer therapy.
- Further research into these interactions can lead to innovative therapeutic strategies.
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