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[Chronic gastrite: modern state of the problem]
O N Minushkin1, I V Zverkov1, N V Lvova2
1Central State Medical Academy of Department of Presidential Affairs.
Terapevticheskii Arkhiv
|December 21, 2020
Summary
Ursodeoxycholic acid (UDCA) effectively treats chronic biliary reflux gastritis. This study found UDCA drugs to be the treatment of choice for this condition, showing significant efficacy in patients.
Area of Science:
- Gastroenterology
- Hepatology
- Pharmacology
Background:
- Chronic gastritis is a prevalent condition with diverse etiologies.
- Biliary reflux gastritis, a subtype, involves bile acid-induced damage.
- Current classifications may not adequately address this specific form.
Purpose of the Study:
- To review current understanding of chronic gastritis.
- To evaluate the efficacy of ursodeoxycholic acid (UDCA) in treating biliary reflux gastritis.
- To advocate for a distinct classification for biliary reflux gastritis.
Main Methods:
- A review of modern concepts in chronic gastritis.
- Clinical study involving 50 patients with chronic biliary reflux gastritis.
- Treatment with Grinterol (a UDCA drug) at 12.5 mg/kg/day for 4 weeks.
Main Results:
- Ursodeoxycholic acid (UDCA) drugs are identified as primary treatment for biliary reflux gastritis.
- Endomorphological efficacy reached 76%, with 100% clinical efficacy.
- The study supports UDCA's role in managing this condition.
Conclusions:
- A new classification recognizing biliary reflux gastritis is warranted.
- UDCA drugs demonstrate high effectiveness in treating chronic biliary reflux gastritis.
- This supports the scientific justification for classifying biliary reflux gastritis separately.
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