Related Experiment Video

Updated: Nov 24, 2025

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
09:42

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

Published on: August 26, 2014

19.1K

Moderate-to-severe Endoscopic Inflammation is Frequent After Clinical Remission in Pediatric Ulcerative Colitis

Chen Sarbagili-Shabat1,2, Dror Weiner1, Joram Wardi3

  • 1PIBD Research center, Paediatric Gastroenterology and Nutrition Unit, The E. Wolfson Medical Center, Holon.

Journal of Pediatric Gastroenterology and Nutrition
|December 21, 2020
PubMed

Insights

In pediatric ulcerative colitis (UC), over half of children achieving clinical remission still show significant endoscopic inflammation, linked to lower sustained remission rates. This highlights the need for deeper assessment beyond symptoms.

Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease Research
  • Mucosal Healing in Ulcerative Colitis

Background:

  • Pediatric ulcerative colitis (UC) often presents with low sustained remission rates and disease progression.
  • Moderate-to-severe endoscopic activity is a known risk factor for relapse in UC patients.
  • Limited prospective data exists on early mucosal healing or persistent inflammation following clinical remission in pediatric UC.

Purpose of the Study:

  • To investigate the prevalence of significant endoscopic inflammation in pediatric UC patients after achieving clinical remission.
  • To determine if persistent inflammation explains the high relapse rates observed in pediatric UC.
  • To evaluate the association between endoscopic healing and sustained remission in pediatric ulcerative colitis.

Main Methods:

  • Prospective assessment of pediatric UC patients with clinical remission (Pediatric UC Activity Index [PUCAI] <10) for mucosal healing via endoscopy.
  • Endoscopic evaluation (Mayo score) conducted 3 to 5 months post-remission by blinded adult gastroenterologists using central reading.
  • Retrospective assessment of sustained remission at 18 months follow-up for patients with documented mucosal healing.

Main Results:

  • Of 28 children in continuous clinical remission, 50% exhibited moderate-to-severe endoscopic inflammation (Mayo 2-3) 3-5 months after remission.
  • Patients with Mayo scores of 0-1 demonstrated higher sustained remission rates (50.0%) compared to those with Mayo 2-3 (18.18%) at 18 months.
  • A significant proportion of children (over 50%) with clinical remission had persistent endoscopic disease activity.

Conclusions:

  • Persistent moderate-to-severe endoscopic inflammation is common in pediatric UC patients achieving clinical remission.
  • Endoscopic disease activity, even after clinical remission, is associated with significantly lower rates of sustained remission.
  • These findings underscore the importance of endoscopic assessment for evaluating treatment response and predicting long-term outcomes in pediatric ulcerative colitis.
Abstract

More Related Videos

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing07:38

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing

Published on: September 13, 2016

8.6K
Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

32.3K

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
659
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
612
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
638
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
322
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
305
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
304