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Targeting Alternative Splicing for Reversal of Cellular Senescence in the Context of Aesthetic Aging

Laura R Bramwell1, Lorna W Harries1

  • 1From the RNA-Mediated Mechanisms of Disease group, College of Medicine and Health, Institute of Biomedical and Clinical Science, University of Exeter.

Plastic and Reconstructive Surgery
|December 21, 2020
PubMed
Abstract

Insights

Cellular senescence, a key aging factor, can be targeted for removal or rejuvenation. Emerging senotherapeutic strategies, including restoring splicing regulation, show promise for treating aging signs and diseases.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Cell Biology

Background:

  • Cellular senescence is linked to aging processes at cellular, tissue, and organismal levels.
  • Targeting senescent cells has shown benefits for healthspan and lifespan in animal models.
  • Novel approaches to eliminate or rejuvenate senescent cells are under investigation for human aging applications.

Purpose of the Study:

  • To review current in vitro and in vivo strategies for senescent cell ablation or rejuvenation.
  • To explore dysregulation of alternative splicing as a potential molecular mechanism driving senescence.
  • To discuss restoring splicing regulation as a novel senotherapeutic approach for skin aging.

Main Methods:

  • Review of existing literature on senescent cell targeting strategies.
  • Discussion of emerging evidence for alternative splicing dysregulation in senescence.
  • Exploration of potential therapeutic interventions for splicing regulation.

Main Results:

  • Various strategies for senescent cell removal and rejuvenation are being trialed.
  • Evidence suggests alternative splicing dysregulation may underlie senescence.
  • Restoring splicing regulation is a potential novel senotherapeutic avenue.

Conclusions:

  • Targeted interventions against cellular senescence offer therapeutic potential for aging.
  • Alternative splicing dysregulation presents a new molecular target for senotherapeutics.
  • Integrating splicing-based therapies could enhance treatments for skin aging.

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