Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

127
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
127
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

127
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
127
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

121
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
121
Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

141
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
141
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

100
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
100
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

273
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
273

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Usefulness of Clot Waveform Analysis-Activated Thromboplastin Time (APTT) for Diagnosing Thrombotic Diseases.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
Same author

Recognizing Coagulation Disorders in Sepsis in the Emergency Room: A Narrative Review.

Journal of clinical medicine·2026
Same author

Evaluation of Autoimmune FVIII Inhibitor Using Clot Waveform Analysis in Emicizumab-Treated Patients.

Journal of clinical medicine·2026
Same author

Diagnostic and Prognostic Evaluation of Disseminated Intravascular Coagulation Using the Disseminated Intravascular Coagulation Index.

Journal of clinical medicine·2025
Same author

Factors influencing antithrombin activity following supplementation in sepsis-associated disseminated intravascular coagulation.

Thrombosis journal·2025
Same author

Evaluation of Deficiency and Excessive Condition of Thrombin Burst Using Laboratory Tests.

Thrombosis and haemostasis·2025

Related Experiment Video

Updated: Nov 24, 2025

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

15.1K

Elevated D-Dimer Levels Predict a Poor Outcome in Critically Ill Patients.

Yuhuko Ichkawa1, Hideo Wada1,2, Minoru Ezaki1

  • 1Department of Central Laboratory, 36941Mie Prefectural General Medical Center, Yokkaichi, Japan.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|December 21, 2020
PubMed
Summary

Elevated D-dimer levels, a marker for thrombosis, indicate a higher risk of poor outcomes in critically ill patients. This finding is crucial for predicting patient survival in infectious disease contexts.

Keywords:
D-dimercritically ill patientspoor outcomethrombosis

More Related Videos

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.6K
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.2K

Related Experiment Videos

Last Updated: Nov 24, 2025

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

15.1K
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.6K
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.2K

Area of Science:

  • Biomarkers
  • Critical Care Medicine
  • Thrombosis

Background:

  • D-dimer is a known biomarker for thrombosis.
  • Emerging evidence suggests D-dimer may predict poor outcomes in infectious diseases.

Purpose of the Study:

  • To investigate the relationship between plasma D-dimer levels and outcomes in critically ill patients.
  • To assess the predictive value of D-dimer for mortality in this patient group.

Main Methods:

  • Plasma D-dimer levels were measured in critically ill patients.
  • Receiver operating characteristic (ROC) analysis was used to evaluate predictive performance.
  • Disseminated intravascular coagulation (DIC) score and prothrombin time-international normalized ratio (PT-INR) were also assessed.

Main Results:

  • D-dimer levels were significantly higher in non-survivors compared to survivors.
  • Higher D-dimer levels were observed in patients with underlying diseases, particularly venous thromboembolism.
  • D-dimer, DIC score, and PT-INR showed high predictive value for poor outcomes, with specific cut-off values identified.

Conclusions:

  • Plasma D-dimer is a valuable biomarker for predicting poor outcomes in critically ill patients.
  • Elevated D-dimer levels, even in the absence of overt thrombosis, are associated with increased mortality risk.
  • D-dimer, alongside DIC score and PT-INR, can aid in risk stratification and outcome prediction.