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Targeting Akt-associated microRNAs for cancer therapeutics

Mir S Adil1, Daulat Khulood1, Payaningal R Somanath1

  • 1Clinical and Experimental Therapeutics, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, United States.

Biochemical Pharmacology
|December 21, 2020
PubMed

Insights

Cancer involves abnormal cell growth driven by gene mutations. MicroRNAs (miRNAs) interact with the Akt pathway, offering potential as cancer biomarkers and therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer is characterized by uncontrolled cell growth due to genetic alterations.
  • The PI3K/Akt pathway is crucial for cell survival and proliferation in cancer.
  • MicroRNAs (miRNAs) are key regulators of gene expression involved in tumorigenesis.

Purpose of the Study:

  • To review the role of Akt-associated miRNAs in various cancers.
  • To explore the molecular regulation of these miRNAs and their interaction with the Akt pathway.
  • To discuss the therapeutic and diagnostic potential of this Akt-microRNA network.

Main Methods:

  • Literature review of studies on Akt-associated miRNAs in cancer.
  • Analysis of molecular mechanisms regulating miRNA expression and function.
  • Examination of miRNA-based therapeutic strategies and biomarkers.

Main Results:

  • Cancer tissues show significant alterations in miRNA expression.
  • A regulatory network exists between miRNAs and the Akt pathway.
  • miRNAs can be modulated using techniques like miRNA mimics and CRISPR/Cas9.

Conclusions:

  • Akt-associated miRNAs are integral to cancer development and progression.
  • This network presents novel opportunities for cancer therapy and early diagnosis.
  • Understanding the Akt-microRNA interplay can revolutionize cancer treatment strategies.
Keywords:
AktBiomarkersCancerMicroRNAsRNA-therapeutics

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