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Peripheral serotoninergic receptor sensitivity in senile dementia of the Alzheimer type
D R Thomas1, E Jones, N Warner
1Department of Psychological Medicine, University of Wales College of Medicine, Whitchurch Hospital, Cardiff, Great Britain.
Biological Psychiatry
|January 15, 1988
Abstract:
Platelet aggregation induced by 5-hydroxytryptamine (5-HT) was used as a measure of the functional responsiveness of peripheral 5-HT receptors in controls and drug-free patients suffering from senile dementia of Alzheimer type (SDAT). No significantly different aggregatory response (5-HT/ADP ratio) was noted between the two groups of subjects. If the receptor mediating this response is a 5-HT2 receptor, there is no evidence to suggest that the functional activity of this system is abnormal in SDAT.