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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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Master Transcription Regulators02:23

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Combinatorial Gene Control02:33

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
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Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
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Somatic to iPS Cell Reprogramming01:29

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Related Experiment Video

Updated: Nov 24, 2025

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
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Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28.

William T Mills1, Noor N Nassar1, Deepa Ravindra1

  • 1Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Cells
|December 22, 2020
PubMed
Summary

The NF-κB transcription factor and Lin28/let-7 pathways regulate cell growth. This review explores their complex interactions in pluripotency, differentiation, and neuroplasticity.

Keywords:
Lin28NF-κBRNA-binding proteinlet-7 microRNAnervous systemneurodevelopmentpluripotencytranscription factor

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Developmental Biology

Background:

  • Nuclear Factor kappa B (NF-κB) and Lin28/let-7 pathways are key regulators of cell survival, growth, and proliferation.
  • Interactions between these pathways are crucial for fundamental biological processes.
  • Understanding these interfaces is vital for advancing research in stem cell biology and neuroscience.

Purpose of the Study:

  • To summarize the NF-κB and Lin28/let-7 pathways.
  • To focus on the signaling interactions at transcriptional and post-transcriptional levels.
  • To highlight convergent findings and suggest future research directions.

Main Methods:

  • Literature review of existing research on NF-κB and Lin28/let-7 pathways.
  • Analysis of signaling interactions at molecular levels.
  • Synthesis of findings across different biological systems.

Main Results:

  • Both NF-κB and Lin28/let-7 pathways act as master regulators in cellular processes.
  • Complex regulatory loops, including feedback mechanisms, exist between these pathways.
  • Interactions influence pluripotency, progenitor differentiation, and neuroplasticity.

Conclusions:

  • The interplay between NF-κB and Lin28/let-7 pathways is critical for cell fate decisions.
  • Further investigation into these interactions will yield significant biological insights.
  • This review provides a foundation for future research in this emerging area.