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[French ccAFU guidelines - update 2020-2022: penile cancer].

P-H Savoie1, N Morel-Journel2, T Murez3

  • 1Comité de Ccancérologie de l'Association française d'urologie, groupe organes génitaux externes, Maison de l'urologie, 11, rue Viète, 75017 Paris, France; Service de chirurgie urologique, hôpital d'instruction des armées Sainte-Anne, 2, boulevard Sainte-Anne, BP 600, 83800 Toulon, Cedex 09, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|December 22, 2020
PubMed
Summary

Penile cancer management requires precise surgical staging, especially for inguinal lymph nodes, which are critical for prognosis. Chemotherapy may be necessary for advanced cases.

Keywords:
Adénopathie inguinaleCancer épidermoïdeEpidermoid carcinomaInguinal adenopathyLymphadenectomyLymphadénectomiePenectomyPenile cancerPénectomiePénis

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Area of Science:

  • Oncology
  • Urology

Background:

  • Penile cancer is a rare but serious malignancy.
  • Accurate staging, particularly of lymph node involvement, is crucial for effective treatment and prognosis.

Purpose of the Study:

  • To update French oncology guidelines for penile cancer diagnosis, treatment, and follow-up.
  • To provide evidence-based recommendations for managing penile cancer, focusing on lymph node assessment.

Main Methods:

  • A comprehensive literature search of Medline (2018-2020) was conducted.
  • Evidence levels were assessed using the AGREE-II framework.
  • Guidelines were updated based on the latest research findings.

Main Results:

  • Epidermoid carcinoma is the most common penile cancer type.
  • Physical examination and imaging (MRI, PET-CT) are vital for staging.
  • Invasive lymph node assessment, including sentinel node biopsy, is recommended due to high rates of micrometastasis.
  • Surgery is the primary treatment, aiming for organ preservation with clear margins.
  • Multidisciplinary treatment, including chemotherapy, is indicated for advanced lymph node involvement.

Conclusions:

  • Lymph node status is a major prognostic factor in penile cancer.
  • Thorough inguinal lymph node assessment is essential for optimal patient outcomes.
  • Penile cancer treatment often requires complex surgery, potentially combined with chemotherapy for node-positive patients.