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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Cognitive Development During Adulthood01:30

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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Theories play an essential role in organizing patient care. Theories refer to a proposed or followed belief, policy, or procedure that is the basis for action. Nursing theories are knowledge-based concepts that guide nurses' actions, influence nursing education and practice, and allow nurses to care for their patients.
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Related Experiment Video

Updated: Nov 24, 2025

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
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Bringing Transdisciplinary Aging Research From Theory to Practice.

Lana Sargent1,2, Patricia Slattum2,3, Marshall Brooks4

  • 1School of Nursing, Virginia Commonwealth University, Richmond, USA.

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Transdisciplinary team science accelerates aging research, but optimal structures are unclear. Internal evaluations and conceptual models are crucial for success in addressing complex issues for older adults.

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Community-engaged researchKnowledge translationTeam science

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Area of Science:

  • Gerontology
  • Team Science
  • Public Health

Background:

  • Aging research increasingly emphasizes transdisciplinary team approaches to tackle complex health and social issues.
  • Optimal organizational structures and processes for effective transdisciplinary team science remain undefined.
  • Effective collaboration is essential for addressing persistent challenges faced by older adults in urban settings.

Purpose of the Study:

  • To share experiences and insights on utilizing transdisciplinary approaches to address challenges in urban aging communities.
  • To describe successes and challenges encountered while applying the National Institutes of Health (NIH) four-phase model of transdisciplinary research.
  • To introduce a novel Transdisciplinary Conceptual Model developed from internal team evaluations.

Main Methods:

  • An internal evaluation using a de-identified survey was conducted to identify challenges within the transdisciplinary team.
  • Key challenges identified included structural incongruities, interprofessional blind spots, group function, and group dynamics.
  • The National Institutes of Health (NIH) four-phase model of transdisciplinary team-based research guided the team's approach.

Main Results:

  • The team developed a Transdisciplinary Conceptual Model to better understand the interplay between societal factors, community partners, and academic partners.
  • Internal evaluations revealed critical factors hindering transdisciplinary integration, such as structural issues and interprofessional communication gaps.
  • The study highlights the importance of internal process evaluation for advancing beyond multidisciplinary or interdisciplinary work to true transdisciplinary success.

Conclusions:

  • Internal evaluations of transdisciplinary team processes are vital for achieving genuine transdisciplinary success.
  • Further research is needed to develop reliable measures for assessing team transdisciplinary integration.
  • Future work should focus on determining the impact of transdisciplinary team science initiatives on aging communities.