Related Experiment Video

Updated: Nov 24, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.5K

Circular RNA in cardiovascular disease: Expression, mechanisms and clinical prospects

Ying Tang1, Jinghui Bao1, Jiahui Hu1

  • 1Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Journal of Cellular and Molecular Medicine
|December 22, 2020
PubMed

Insights

Circular RNAs (circRNAs) are key regulators in heart disease. These stable molecules show potential as diagnostic and prognostic biomarkers for cardiovascular diseases (CVDs).

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiology

Background:

  • Circular RNAs (circRNAs) are endogenous, non-coding RNAs with a unique covalently closed structure.
  • They are widely expressed in human tissues, including the heart, and play regulatory roles.

Purpose of the Study:

  • To provide a comprehensive understanding of circRNAs, focusing on their role in the cardiovascular system.
  • To review the classification, biogenesis, properties, and involvement of circRNAs in cardiovascular disease (CVD) pathogenesis.

Main Methods:

  • Literature review of current research on circRNAs.
  • Systematic summary of circRNA classification, biogenesis, properties, and roles in CVD.

Main Results:

  • CircRNAs are conserved, stable molecules with specific spatiotemporal expression patterns.
  • Evidence indicates significant regulatory functions of cardiac circRNAs in CVDs.
  • CircRNAs possess characteristics suitable for biomarker applications.

Conclusions:

  • CircRNAs are implicated in the pathogenesis of cardiovascular diseases.
  • Their stability and specific expression make them promising diagnostic and prognostic biomarkers for CVDs.

Keywords:
RNA-binding proteinbiogenesiscardiovascular diseasecircRNAmiRNA

More Related Videos

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.8K
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.7K

Related Concept Videos

Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
3.0K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
202
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.3K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
676
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
232
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.9K