Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Specific chromosomal abnormalities in malignant human gliomas.

S H Bigner1, J Mark, P C Burger

  • 1Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710.

Cancer Research
|January 15, 1988
PubMed
Summary

Karyotypic analysis reveals specific chromosomal abnormalities in human gliomas. Near-diploid gliomas frequently show gains of chromosome 7 and losses of chromosome 10, aiding future gene investigations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulsed electromagnetic field stimulation may improve fusion rates in cervical arthrodesis in high-risk populations.

Bone & joint research·2018
Same author

Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations.

Neuropathology and applied neurobiology·2013
Same author

Bevacizumab continuation beyond initial bevacizumab progression among recurrent glioblastoma patients.

British journal of cancer·2012
Same author

Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation.

Oncogene·2010
Same author

Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.

British journal of cancer·2009
Same author

Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.

Molecular pharmacology·2009

Area of Science:

  • Cytogenetics
  • Neuro-oncology
  • Cancer Genomics

Background:

  • Malignant gliomas are aggressive brain tumors with complex genetic alterations.
  • Understanding specific chromosomal abnormalities is crucial for identifying potential therapeutic targets.

Purpose of the Study:

  • To perform karyotypic analysis on a cohort of malignant human gliomas.
  • To identify statistically significant numerical and structural chromosomal aberrations in near-diploid gliomas.

Main Methods:

  • Karyotypic analysis of 54 malignant human gliomas.
  • Statistical analysis of numerical deviations (chromosome gains/losses) and structural abnormalities (breakpoints).
  • Comparison of breakpoint incidence to expected values based on chromosomal arm length.

Related Experiment Videos

Main Results:

  • Twelve of 54 gliomas had normal stemlines or lacked a sex chromosome.
  • Among 38 fully analyzed abnormal karyotypes, 32 were near-diploid.
  • Statistically significant numerical deviations in near-diploid gliomas included gains of chromosome 7 (26/32) and losses of chromosome 10 (19/32).
  • Structural abnormalities of 9p and 19q were statistically significant.
  • Double minutes were observed in 18/32 near-diploid tumors.

Conclusions:

  • Specific numerical and structural chromosomal abnormalities characterize near-diploid malignant gliomas.
  • Gains of chromosome 7 and losses of chromosome 10 are common in these tumors.
  • Identified chromosomal aberrations provide a foundation for investigating genes altered in glioma development and progression.