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Updated: Nov 24, 2025

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Usual opioid dosing does not adversely affect the course of healthcare-associated Clostridioides difficile infection
Monica Chowdhry1, Douglas Haden2, Suzanne Kemper1
1West Virginia University Health Sciences Center, Charleston Division/Charleston Area Medical Center, Charleston, WV 25304, USA.
Abstract:
Aim: We sought to determine if opioid exposure may have a detrimental effect on the course of Clostridioides difficile infection (CDI). Materials & methods: We compared opioid exposure in patients with well-defined severe CDI and non-severe CDI. Results: Following exclusions, 403 records were reviewed. Of this group, 128/403 (31.7%) were determined to have severe CDI by strict criteria, and 275/403 (68.3%) were found to have non-severe CDI. Full multivariate regression and reduced model of potential predictors for severe CDI showed no association with opioids prescribed. Conclusion: Opioid exposure (predominantly in modest range) does not appear to be a risk factor for severe healthcare-associated CDI.
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