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Updated: Nov 24, 2025

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Allergen sensitization associates with worse lung function parameters
I Gonçalves1,2,3, A M Pereira1,2,4, T A Queirós Jacinto2,3,4,5
1Allergy Unit, Instituto and Hospital CUF, Porto, Portugal.
Summary:
Objective. To assess the association between the number of allergen sensitizations and lung function variables in individuals with airway symptoms. Methods. Retrospective study with all individuals who performed lung function and skin-prick tests at CUF-Porto (01/2011-06/2016). Six allergen groups were considered. % predicted Pre-Bronchodilator test (BD) and % change after BD were analysed for spirometry and plethysmography parameters. Results. A total of 1293 individuals were included, 54% (n = 698) adults and 69% (n = 891) with sensitization to ≥ 1 allergen group. % FEV1 was significantly higher and % change in FEV1 significantly lower in non-sensitized individuals. % sRaw was higher in polysensitized (vs non-sensitized). Conclusions. The presence of allergen sensitizations was significantly associated with worse key lung function parameters.
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