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Intravenous vs intraosseous adrenaline administration in cardiac arrest: A protocol for systematic review and

Wei Zhang1,2, Yi Liu1,2, Jing Yu2

  • 1Department of Emergency Medicine, Laboratory of Emergency Medicine, West China Hospital, and Disaster Medical Center.

Medicine
|December 22, 2020
PubMed

Insights

This study compares intravenous versus intraosseous adrenaline administration for cardiac arrest. It aims to determine the optimal delivery method for improving resuscitation outcomes and patient survival.

Area of Science:

  • Emergency Medicine
  • Cardiology
  • Clinical Research

Background:

  • Cardiac arrest necessitates prompt intervention, with adrenaline being a critical resuscitation drug.
  • Current adrenaline delivery methods include intraosseous infusion and intravenous access, but their comparative effectiveness is unclear.
  • This study addresses the need for evidence-based guidance on optimal adrenaline administration routes in cardiac arrest.

Purpose of the Study:

  • To synthesize evidence comparing intravenous versus intraosseous adrenaline administration in cardiac arrest.
  • To identify the most effective route for adrenaline delivery to improve patient outcomes.
  • To inform clinical decision-making in the management of cardiac arrest.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials (RCTs).
  • Searches of major databases including PubMed, EMBASE, and Cochrane Library.
  • Assessment of bias risk using Cochrane's tool and certainty of evidence with GRADE approach.

Main Results:

  • Primary outcome: prehospital restoration of spontaneous circulation (ROSC).
  • Secondary outcomes: survival, favorable and poor neurological outcomes at discharge and follow-up.
  • Meta-analysis will be conducted using fixed or random effects models based on heterogeneity.

Conclusions:

  • This protocol will establish the optimal epinephrine delivery method for cardiac arrest management.
  • Findings will guide clinicians in making informed decisions regarding adrenaline administration.
  • Evidence synthesis will enhance resuscitation protocols and patient care.
Abstract

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