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A Micropatterning Assay for Measuring Cell Chirality
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Molecular Chirality Detection with Periodic Arrays of Three-Dimensional Twisted Metamaterials
Chia-Yi Lin1, Chi-Ching Liu2,3, Yu-Yu Chen1
1Department of Photonics, National Cheng Kung University, Tainan 701, Taiwan.
ACS Applied Materials & Interfaces
|December 22, 2020
Summary
This study introduces a rapid optical method using 3D twisted metamaterials for chiral drug detection. The technique accurately identifies the handiness of Thalidomide, crucial for pharmaceutical safety.
Area of Science:
- Nanophotonics
- Chiral Metamaterials
- Spectroscopy
Background:
- Chiral molecule handiness is critical in pharmaceuticals due to potential side effects of different enantiomers.
- Accurate and rapid detection methods are needed to ensure drug safety and efficacy.
Purpose of the Study:
- To develop a rapid optical method for determining the handiness of chiral molecules, specifically the drug Thalidomide.
- To demonstrate the use of 3D twisted metamaterials for chiral detection.
Main Methods:
- Fabrication of large-area 3D twisted metamaterials using a combination of nanospherical-lens lithography (NLL) and hole-mask lithography (HML).
- Utilizing the strong circular dichroism (CD) response in the near-infrared (NIR) region for chiral detection.
Main Results:
- Observation of a strong CD response in the NIR region, enabling sensitive chiral detection.
- Successful demonstration of a high-throughput fabrication method for 3D metamaterials.
- Development of a method compatible with low-cost, portable spectroscope systems.
Conclusions:
- The proposed method offers a rapid and effective way to determine chiral drug handiness.
- The advanced nanofabrication technique enhances NLL and HML capabilities for creating various 3D metamaterials.
- This research facilitates the integration of nanophotonics into the pharmaceutical industry for enhanced drug analysis.
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