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Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda
Emerging Infectious Diseases
|December 22, 2020
Abstract:
Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.
