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Updated: Nov 24, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Relationships of interleukin-17 polymorphisms with recurrent aphthous ulcer risk in a Han Chinese population
Haidong Xiang1, Dongmei Cheng1, Han Guo1
1Department of Oral Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Objective:
Interleukin (IL)-17 is a multifunctional cytokine with important roles in inflammatory and autoimmune diseases. This case-control study explored the relationships of IL-17A rs2275913 and IL-17F rs763780 single-nucleotide polymorphisms (SNPs) with recurrent aphthous ulcer (RAU) morbidity and severity.
Methods:
IL-17A rs2275913 and IL-17F rs763780 SNPs were measured in 125 patients with RAU and 116 healthy control participants. The genotype distributions, disease risks, and relationships with RAU severity were analyzed.
Results:
RAU risk was associated with rs2275913 after adjustment for age, body mass index, sex, smoking status, and drinking status (AA vs. GG: odds ratio [OR], 2.759; 95% confidence interval [CI], 1.381-5.512; A allele vs. G allele: OR, 1.783; 95% CI, 1.242-2.560). TC and CC genotypes in rs763780, and the corresponding C allele, demonstrated greater prevalence among patients with RAU, compared with the TT genotype (TC vs. TT, OR: 1.895; 95% CI: 1.088-3.301; CC vs. TT, OR: 4.080, 95% CI: 1.079-15.425; C allele vs. T allele, OR: 1.969, 95% CI: 1.257-3.083). Serum IL-17 concentrations were also higher in patients with RAU than in control participants. These concentrations were associated with IL-17 polymorphisms.
Conclusions:
IL-17 polymorphisms might be associated with greater risk of RAU pathogenesis.
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