The cytotoxicity of core-shell or non-shell structure quantum dots and reflection on environmental friendly: A review

Quantum dots are widely applicated into bioindustry and research owing to its superior properties such as broad excitation spectra, narrow bandwidth emission spectra and high resistance to photo-bleaching. However, the toxicity of quantum dots should not be underestimated and aroused widespread concern. The surface properties and size of quantum dots are critical relevant properties on toxicity. Then, the core/shell structure becomes one common way to affect the activity of quantum dots such as enhance biocompatibility and stability. Except those toxicity it induced, the problem it brought into the environment such as the degradation of quantum dot similarly becomes a hot issue. This review initially took a brief scan of current research on the cytotoxicity of QDs and the mechanism behind that over the past five years. Mainly discussion concentrated on the diversity of structure on quantum dots whether played a key role on the cytotoxicty of quantum dots. It also discussed the role of different shells with metal or nonmetal cores and the influence on the environment.