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Related Concept Videos

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

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Expression of adult globin mRNAs in hamster yolk-sac erythroid cells during ontogeny.

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The globin gene expression program in the hamster embryo.

T Boussios1, J F Bertles

  • 1Hematology-Oncology Division, St. Luke's-Roosevelt Hospital Center, New York, NY 10025.

Experimental Hematology
|January 1, 1988
PubMed
Summary

Hamster yolk-sac cells show a complete embryonic to adult globin gene expression switch during development. This finding offers insights into globin ontogeny and potential treatments for hemoglobin disorders.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Globin gene expression regulation is key in basic research and for treating hemoglobinopathies.
  • Rodent yolk-sac cells contain both embryonic and adult globins, suggesting a role in globin ontogeny.

Purpose of the Study:

  • To investigate the extent of globin ontogeny in hamster yolk-sac erythroid cells.
  • To define the developmental timeline of globin synthesis in these primitive cells.

Main Methods:

  • Quantified daily rates of individual globin synthesis in hamster yolk-sac erythroid cells.
  • Analyzed globin synthesis from day 7 to day 13 of gestation.

Main Results:

  • Demonstrated an ontogenic progression from embryonic to adult globin synthesis on a per-cell basis.
  • Adult alpha-globin synthesis detected by day 7; adult beta-globins appeared by day 9.
  • Embryonic y-globin synthesis increased as x and z-globins decreased, mirroring primate patterns.

Conclusions:

  • Hamster yolk-sac erythroid cells exhibit a comprehensive globin ontogeny.
  • These primitive cells are valuable models for studying globin gene expression and development.
  • Findings may inform strategies for ameliorating human hemoglobinopathies.