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Updated: Nov 24, 2025

A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
Djuro Kosanovic1, Andrey I Yaroshetskiy1, Natalia A Tsareva1
1I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Abstract:
Existing literature highlights the fact that patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. In this report, we describe the effects of systemic thrombolysis on acute cor pulmonale in a patient suffering from COVID-19. We demonstrated that systemic thrombolysis successfully improved the hemodynamics of our patient and resulted in a prominent reduction in hypercapnia, alveolar dead space, and ventilatory ratio.
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