Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

3.6K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
3.6K
Fatigue01:21

Fatigue

507
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
507
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

654
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
654
Factors Affecting Illness01:18

Factors Affecting Illness

4.8K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.8K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.1K
Types of Stressors01:23

Types of Stressors

469
A stressor is any event, condition, or stimulus that triggers stress and causes a physical or psychological response in the body. Stressors can be categorized into three main types: catastrophes; significant life changes; and daily hassles, including social stress. Each can be detrimental to physical and mental well-being.
Catastrophes
Catastrophes refer to large-scale, unpredictable events that create overwhelming stress and a sense of threat. Examples include natural disasters like...
469

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The dual diversity crisis in alzheimer's disease research: why neuroimaging biomarkers and clinical trials keep failing.

GeroScience·2026
Same author

Correction: Rudroff, T. Artificial Intelligence as a Replacement for Animal Experiments in Neurology: Potential, Progress, and Challenges. <i>Neurol. Int.</i> 2024, <i>16</i>, 805-820.

Neurology international·2026
Same author

A Dual Diversity Crisis in fNIRS-Based TBI Rehabilitation Research.

The Journal of head trauma rehabilitation·2026
Same author

Beyond group averages: why motor control studies must address population and individual heterogeneity.

Journal of neurophysiology·2026
Same author

Reply to: "comment on 'spinal cord metabolism in multiple sclerosis: a decade of missed opportunities and future directions".

Spinal cord·2026
Same author

The dual diversity crisis in EEG biomarker research for cognitive fatigue.

Psychological medicine·2026

Related Experiment Video

Updated: Nov 24, 2025

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

498

Post-COVID-19 Fatigue: Potential Contributing Factors.

Thorsten Rudroff1,2, Alexandra C Fietsam1, Justin R Deters1

  • 1Department of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USA.

Brain Sciences
|December 23, 2020
PubMed
Summary

Post-COVID-19 fatigue significantly impacts recovered patients, affecting physical and mental performance. This perspective defines fatigue and proposes a model to understand its contributing factors.

Keywords:
COVID-19fatiguerecovery

More Related Videos

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

453
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.4K

Related Experiment Videos

Last Updated: Nov 24, 2025

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

498
The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

453
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.4K

Area of Science:

  • Medical research
  • Neuroscience
  • Psychology

Background:

  • Coronavirus disease 2019 (COVID-19) recovery often includes persistent physical, cognitive, and psychological symptoms.
  • Fatigue is a particularly common and debilitating long-term symptom following COVID-19 infection.

Purpose of the Study:

  • To define post-COVID-19 fatigue.
  • To propose a model explaining the factors contributing to persistent fatigue after COVID-19.

Main Methods:

  • This perspective article defines fatigue in the context of COVID-19.
  • A conceptual model is proposed, outlining conditional and physiological factors influencing fatigue.

Main Results:

  • Fatigue is defined as decreased physical and/or mental performance due to central, psychological, or peripheral factors from COVID-19.
  • The proposed model posits that fatigue is influenced by conditional factors (task, environment, individual capacity) and physiological factors (central, psychological, peripheral).

Conclusions:

  • The proposed model offers a framework for understanding and addressing post-COVID-19 fatigue.
  • Further research is required to validate the model and fully understand the mechanisms of COVID-19-related fatigue.