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3D-Printed Veterinary Dosage Forms-A Comparative Study of Three Semi-Solid Extrusion 3D Printers.

Erica Sjöholm1, Rathna Mathiyalagan1, Dhayakumar Rajan Prakash1

  • 1Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, Finland.

Pharmaceutics
|December 23, 2020
PubMed
Summary

3D printing offers a solution for veterinary medicine's dosage problem. The Allevi 2 bioprinter successfully created personalized prednisolone orodispersible films for animals, meeting quality standards.

Keywords:
3D printingadditive manufacturingdrug deliveryextemporaneous manufacturingpersonalized dosage formsprednisolonesemi-solid extrusion 3D printingveterinary medicine

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Area of Science:

  • Veterinary Pharmacy
  • 3D Printing Technology
  • Pharmaceutical Sciences

Background:

  • Limited approved veterinary medicines necessitate off-label human drug use.
  • Existing human medications often have potencies unsuitable for cats and small dogs.
  • There is a significant need for customized, lower-dose veterinary medications.

Purpose of the Study:

  • To evaluate three semi-solid extrusion 3D printers for extemporaneous manufacturing.
  • To produce prednisolone-containing orodispersible films for veterinary use.
  • To assess the suitability of 3D printing for point-of-care veterinary drug formulation.

Main Methods:

  • Three semi-solid extrusion 3D printers were tested in a simulated pharmacy/animal clinic setting.
  • Prednisolone orodispersible films were manufactured using the printers.
  • Film quality was assessed for content uniformity, mechanical strength, pH, and moisture content according to European Pharmacopoeia standards.

Main Results:

  • The Allevi 2 bioprinter successfully produced orodispersible films meeting European Pharmacopoeia standards.
  • Films exhibited adequate content uniformity, flexibility, and high mechanical strength.
  • A strong correlation was observed between the designed dosage and the actual drug content in the films.

Conclusions:

  • The Allevi 2 bioprinter is a viable tool for the extemporaneous, point-of-care manufacturing of personalized veterinary medicines.
  • 3D printing enables the creation of tailored doses of prednisolone orodispersible films for animals.
  • This technology addresses the critical need for appropriate dosing in veterinary pharmacotherapy.