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Related Experiment Video

Updated: Nov 24, 2025

In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments
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Food Implications in Central Sensitization Syndromes.

Elena Aguilar-Aguilar1, Helena Marcos-Pasero1, Maria P Ikonomopoulou2,3

  • 1Nutrition and Clinical Trials Unit, GENYAL Platform IMDEA-Food Institute, CEI UAM + CSIC, 28049 Madrid, Spain.

Journal of Clinical Medicine
|December 23, 2020
PubMed
Summary

Dietary modifications can significantly improve the quality of life for patients with central sensitization syndromes (CSS), including fibromyalgia (FM), chronic fatigue syndrome (CFS), and multiple chemical sensitivity (MCS). Personalized nutrition plans are recommended, emphasizing professional guidance to avoid adverse effects.

Keywords:
additivescentral sensitization syndromeschronic fatigue syndromedietary interventionsfibromyalgiafunctional somatic syndromesmicronutrient deficienciesmultiple chemical sensitivitynutritional supplements

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Area of Science:

  • Clinical Nutrition
  • Immunology
  • Dietary Interventions

Background:

  • Central sensitization syndromes (CSS), including fibromyalgia (FM), chronic fatigue syndrome (CFS), and multiple chemical sensitivity (MCS), present complex diagnostic challenges and require multifaceted treatment approaches.
  • The role of nutrition in CSS management, particularly for MCS, remains under-researched with conflicting scientific literature.
  • High interindividual heterogeneity and multi-syndromic patient profiles necessitate individualized therapeutic strategies.

Purpose of the Study:

  • To review and synthesize current scientific evidence on dietary recommendations for CSS patients.
  • To discuss the role of special diets, additives, micronutrient deficiencies, supplements, and nutrient elimination in managing CSS.
  • To provide insights into appropriate nutritional treatment strategies for CSS.

Main Methods:

  • Comprehensive literature review of dietary interventions for central sensitization syndromes.
  • Analysis of evidence regarding special diets, food additives, micronutrients, and supplements.
  • Discussion of scientific findings to inform nutritional management.

Main Results:

  • Dietary modifications show potential for substantial, low-cost improvements in patient quality of life.
  • Personalized treatment plans, considering disease severity, comorbidities, and individual tolerances, are crucial for effective nutritional interventions.
  • Evidence on nutritional interventions for MCS is particularly scarce, highlighting a need for further research.

Conclusions:

  • Personalized dietary interventions are recommended for managing central sensitization syndromes (CSS).
  • Tailoring nutritional plans to individual patient characteristics can enhance quality of life.
  • Close supervision by dietitians and clinicians is essential when implementing dietary guidelines to ensure safety and efficacy.