Related Experiment Video
Updated: Nov 24, 2025
A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
Published on: July 25, 2022
Yersinia Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague
Andrey A Byvalov1,2, Ilya V Konyshev1,2, Vladimir N Uversky3,4
1Komi Research Center, Laboratory of Microbial Physiology, Institute of Physiology, Ural Branch, Russian Academy of Sciences, 167982 Syktyvkar, Russia.
Abstract:
Despite the relatively low incidence of plague, its etiological agent, Yersinia pestis, is an exceptional epidemic danger due to the high infectivity and mortality of this infectious disease. Reports on the isolation of drug-resistant Y. pestis strains indicate the advisability of using asymmetric responses, such as phage therapy and vaccine prophylaxis in the fight against this problem. The current relatively effective live plague vaccine is not approved for use in most countries because of its ability to cause heavy local and system reactions and even a generalized infectious process in people with a repressed immune status or metabolic disorders, as well as lethal infection in some species of nonhuman primates. Therefore, developing alternative vaccines is of high priority and importance. However, until now, work on the development of plague vaccines has mainly focused on screening for the potential immunogens. Several investigators have identified the protective potency of bacterial outer membrane vesicles (OMVs) as a promising basis for bacterial vaccine candidates. This review is aimed at presenting these candidates of plague vaccine and the results of their analysis in animal models.
Insights
Developing novel plague vaccines is crucial due to drug-resistant Yersinia pestis strains and limitations of current vaccines. Bacterial outer membrane vesicles (OMVs) show promise as a basis for new plague vaccine candidates.
Area of Science:
- Microbiology
- Immunology
- Vaccinology
Background:
- Plague, caused by *Yersinia pestis*, poses a significant epidemic threat due to high infectivity and mortality.
- Emerging drug-resistant strains necessitate alternative control strategies beyond antibiotics.
- Current live plague vaccines have safety concerns, including severe reactions and generalized infections, limiting their use.
Purpose of the Study:
- To review the development of novel plague vaccine candidates.
- To evaluate the potential of bacterial outer membrane vesicles (OMVs) as a vaccine platform.
- To present findings from animal model studies of OMV-based plague vaccines.
Main Methods:
- Review of scientific literature on plague vaccine development.
- Analysis of studies investigating bacterial outer membrane vesicles (OMVs) for immunogenicity and protective efficacy.
- Examination of results from animal model studies assessing OMV-based vaccine candidates.
Main Results:
- Bacterial outer membrane vesicles (OMVs) have demonstrated protective potential against *Yersinia pestis* infection.
- OMVs represent a promising platform for developing safer and more effective plague vaccines.
- Preclinical studies in animal models indicate the efficacy of OMV-based vaccine candidates.
Conclusions:
- Alternative plague vaccine strategies are urgently needed.
- Bacterial outer membrane vesicles (OMVs) are a viable and promising approach for next-generation plague vaccines.
- Further research and development of OMV-based vaccines are warranted to combat plague effectively.
More Related Videos
Related Concept Videos
01:18Outer Layers of the Cell Envelope
01:19Formation of Lipopolysaccharides