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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Related Experiment Video

Updated: Apr 4, 2026

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

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Zinc-induced copper deficiency.

H N Hoffman1, R L Phyliky, C R Fleming

  • 1Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

Gastroenterology
|February 1, 1988
PubMed
Summary

Excessive zinc intake caused copper deficiency anemia and low white blood cell counts. Intravenous copper corrected these hematologic abnormalities, suggesting zinc blocks copper absorption.

Area of Science:

  • Hematology
  • Nutritional Science
  • Toxicology

Background:

  • Excessive zinc supplementation can lead to adverse health effects.
  • Copper deficiency can manifest with hematological abnormalities similar to iron deficiency.

Observation:

  • A patient presented with hypochromic-microcytic anemia, leukopenia, and neutropenia.
  • Initial iron therapy was ineffective in resolving the anemia.
  • Oral copper supplementation also failed to correct the hematological issues.

Findings:

  • The patient's symptoms resolved only after intravenous administration of cupric chloride.
  • This suggests a persistent blockage of copper absorption due to excessive zinc.
  • Serum copper and ceruloplasmin levels normalized post-intravenous copper treatment.

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Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
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Implications:

  • High-dose oral zinc intake can induce significant copper deficiency.
  • Intravenous copper administration may be necessary to overcome zinc-induced copper malabsorption.
  • Clinical awareness of zinc-copper interactions is crucial for preventing and treating related deficiencies.