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Published on: August 11, 2015
Clinical Outcomes of Large (>10 mm) Unruptured Posterior Circulation Aneurysms and Their Predictors
Joonho Byun1, Wonhyoung Park1, Jung Cheol Park1
1Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Insights
Treatment for large posterior circulation aneurysms is complex. While both transcranial surgery and endovascular treatment (EVT) have similar complication rates and obliteration success, surgery offers better long-term durability.
Area of Science:
- Neurosurgery
- Vascular Neurology
- Interventional Radiology
Background:
- Large aneurysms in the posterior circulation present significant treatment challenges.
- Managing these complex vascular lesions requires careful consideration of risks and benefits.
Purpose of the Study:
- To analyze institutional clinical outcomes for patients with large, unruptured posterior circulation aneurysms.
- To compare the efficacy and safety of transcranial surgery versus endovascular treatment (EVT).
Main Methods:
- Retrospective analysis of 56 patients with large (>10 mm) unruptured posterior circulation aneurysms (2002-2018).
- Patients were treated with either transcranial surgery or EVT.
- Outcomes including complications, obliteration rates, recurrence, and functional status were assessed.
Main Results:
- No significant difference in post-treatment complications or complete obliteration rates between transcranial surgery and EVT.
- Higher recurrence rates were observed with EVT compared to transcranial surgery (39.5% vs. 11.1%, p=0.03).
- 84% of patients achieved a favorable functional outcome; EVT was a negative predictor of worsening functional status in saccular aneurysms.
Conclusions:
- Treatment of large posterior circulation aneurysms carries a high risk of morbidity.
- Transcranial surgery demonstrated superior treatment durability compared to EVT, despite similar complication and obliteration rates.
- Surgical intervention may be preferred for long-term durability in select cases.
Objective:
The treatment of large aneurysms of the posterior circulation is complicated and remains challenging. We here analyzed our institutional clinical outcomes of large unruptured aneurysms of the posterior circulation.
Methods:
This study included 56 patients who presented with a large (>10 mm) unruptured aneurysm of the posterior circulation between 2002 and 2018.
Results:
There were 18 (32.1%) male and 38 (67.9%) female patients, with a mean age of 53.4 years. The most common location was the vertebral artery, followed by the basilar tip and posterior cerebral artery. The median follow-up duration was 29 months. Eighteen patients (32.1%) were treated by transcranial surgery and 38 (67.9%) were treated by endovascular treatment (EVT). Posttreatment complications occurred in 16 patients (28.6%), with there being no significant difference between the transcranial surgery and EVT groups. Complete obliteration was achieved in 30 patients (53.6%), with there being no statistically significant difference between the transcranial surgery and EVT groups. Recurrence occurred in 17 patients (30.4%), and the rate of recurrence was higher in the EVT group than in the transcranial surgery group (39.5% vs. 11.1%, p=0.03). Forty-four (84%) of 56 patients showed a favorable functional outcome. In saccular aneurysm, EVT was negative predictor of worsening of functional status.
Conclusion:
Treatment of these aneurysms harbors an inherent high risk of morbidity. No superiority was found between transcranial surgery and EVT in terms of complications and complete obliteration, but transcranial surgery showed a higher treatment durability than EVT.
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