HaNDL Syndrome Presenting With Confusion: A Rare Case Report
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Updated: Nov 24, 2025

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Published on: March 11, 2021
Türkan Acar1, Bilgehan Atılgan Acar1, Mustafa Karabacak1
1Sakarya University, Faculty of Medicine, Neurology Department, Sakarya, Turkey.
Abstract:
HaNDL syndrome (Syndrome of Transient Headache and Neurologic Deficit with Cerebrospinal Fluid Lymphocytosis) characterized by sudden onset headache, transient neurological deficits, and cerebrospinal fluid (CSF) lymphocytosis, is a self-limited clinical entity that is rarely seen. In this article, we present a case with HaNDL syndrome in a 28-year-old male patient who presented with confusion and agitation after sudden onset of headache, right hemiparesis, and lymphocytosis pleocytosis.
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