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Atopic Dermatitis and Psoriasis as Overlapping Syndromes.
A Bozek1, M Zajac2,3, M Krupka1
1Clinical Department of Internal Medicine, Dermatology and Allergology, Medical University of Silesia, Katowice, Poland.
Mediators of Inflammation
|December 23, 2020
Summary
Atopic dermatitis (AD) and psoriasis (PS) can occur together in children. Elevated Interleukin-17 (IL-17) levels suggest T helper 17 cells play a key role in coexisting AD and PS.
Area of Science:
- Pediatric Dermatology
- Immunology
Background:
- Atopic dermatitis (AD) and psoriasis (PS) are common inflammatory skin conditions in children.
- The coexistence of AD and PS presents unique clinical challenges and requires further investigation into underlying mechanisms.
Purpose of the Study:
- To investigate the clinical characteristics and immunological profiles of children with concomitant AD and PS.
- To compare these findings with children having either AD or PS alone.
Main Methods:
- An observational study comparing 38 children with AD and PS to 41 with AD only and 28 with PS only.
- Dermatological examinations including SCORAD and PASI scores were performed.
- Cytokine levels (including IL-17) were measured using ELISA.
Main Results:
- Children with concomitant AD and PS were more likely to be boys, overweight, and have a family history of atopic disease.
- Significantly higher concentrations of IL-17 were observed in children with combined AD and PS compared to those with AD only (p=0.01) or PS only (p=0.03).
Conclusions:
- Atopic dermatitis and psoriasis can coexist in pediatric patients.
- The findings highlight a potentially more significant role for T helper 17 cells in the pathogenesis of coexisting AD and PS.
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