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Reversed Septal Curvature Is Associated with Elevated Troponin Level in Hypertrophic Cardiomyopathy

Renata Rajtar-Salwa1, Tomasz Tokarek1, Paweł Petkow Dimitrow2

  • 1Department of Cardiology and Cardiovascular Interventions, University Hospital, Jakubowskiego 2 St., 30-688 Krakow, Poland.

Disease Markers
|December 23, 2020
PubMed

Insights

Reversed septal curvature (RSC) in hypertrophic cardiomyopathy patients is linked to higher high-sensitivity troponin I (hs-TnI) levels and increased provocable left ventricular outflow tract gradient (LVOTG). This suggests RSC may indicate a higher risk of ischemic events.

Area of Science:

  • Cardiology
  • Echocardiography
  • Biomarkers

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
  • Septal configuration is a key echocardiographic feature in HCM.
  • The clinical significance of reversed septal curvature (RSC) in HCM requires further elucidation.

Purpose of the Study:

  • To compare clinical and echocardiographic parameters in HCM patients stratified by septal configuration.
  • To investigate the association between reversed septal curvature (RSC) and biomarkers like hs-TnI and NT-proBNP.
  • To assess the relationship between RSC and left ventricular outflow tract gradient (LVOTG).

Main Methods:

  • Retrospective analysis of 56 consecutive hypertrophic cardiomyopathy patients.
  • Classification into reversed septal curvature (RSC) and non-RSC groups based on 4-chamber apical window views.
  • Comparison of high-sensitivity troponin I (hs-TnI), NT-proBNP, and provocable left ventricular outflow tract gradient (LVOTG) between groups.

Main Results:

  • Patients with RSC exhibited significantly higher levels of hs-TnI (p=0.001).
  • A trend towards increased NT-proBNP was observed in the RSC group (p=0.056).
  • Provocable LVOTG was significantly higher in patients with RSC (p=0.04), alongside prognostically unfavorable septal thickness.

Conclusions:

  • Reversed septal curvature (RSC) in hypertrophic cardiomyopathy is associated with elevated hs-TnI levels.
  • RSC may serve as a marker for increased risk of ischemic events in HCM patients.
  • Provocable LVOTG is a significant finding in patients with RSC.

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