Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Water Intake01:25

Regulation of Water Intake

2.3K
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
2.3K
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

206
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
206
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

203
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
203
Disorder of Water Balance01:29

Disorder of Water Balance

2.1K
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
2.1K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

134
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
134
Regulation of Water Output01:26

Regulation of Water Output

1.7K
The human body predominantly expels water through the urinary system. On average, an individual generates around 1.5 liters of urine each day. This amount can fluctuate based on how well a person is hydrated, but a critical minimum quantity of urine must be produced to ensure the body's proper functioning. Daily, the kidneys remove 600 to 1200 milliosmoles of dissolved substances, effectively excreting excess minerals and water-soluble toxins such as creatinine, urea, and uric acid from the...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial Ultrastructure, Fission Proteins, Activity, and Motor Dysfunctions in the Innovative Parkinson's Disease Model Induced by Manganese Inhalation.

Toxics·2026
Same author

The Role of the Apelin Receptor in the Pathophysiology of Pulmonary Arterial Hypertension.

Cells·2026
Same author

Mitochondrial Dysfunction Drives Oxidative Stress and Energy Imbalance in a Murine Model of Spondyloarthritis.

Cell biochemistry and function·2025
Same author

Fenofibrate as a Modulator of the Renin-Angiotensin System in Su/Hx-Induced Pulmonary Arterial Hypertension.

International journal of molecular sciences·2025
Same author

Early Administration of N-Acetylcysteine Provides Renal and Cardiac Mitochondrial and Redox Protection, Preventing the Development of Cardio-Renal Syndrome Type IV Induced by 5/6NX.

Antioxidants (Basel, Switzerland)·2025
Same author

The interplay of NAD+, hyperuricemia, and renal damage: A scientific review.

Pathology, research and practice·2025

Related Experiment Video

Updated: Nov 24, 2025

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.0K

Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage.

Fernando E García-Arroyo1, Edilia Tapia1, Itzel Muñoz-Jiménez1

  • 1Dept. of Cardio-Renal Physiopathology, INC Ignacio Chávez, Mexico City, Mexico.

Oxidative Medicine and Cellular Longevity
|December 23, 2020
PubMed
Summary

Consuming sugar-sweetened beverages (SB) alongside fluid restriction exacerbates kidney damage by activating specific pathways, unlike water or stevia. These hydration habits may pose a risk factor for kidney disease.

More Related Videos

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.7K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.2K

Related Experiment Videos

Last Updated: Nov 24, 2025

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.0K
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.7K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.2K

Area of Science:

  • Nephrology
  • Metabolic Health
  • Nutritional Science

Background:

  • Paradoxical low water intake alongside high sugar-sweetened beverage (SB) consumption is prevalent.
  • These habits correlate with increased metabolic derangements and chronic disease mortality.
  • Heat dehydration and SB intake stimulate vasopressin release and polyol-fructokinase pathway, mediated by oxidative stress.

Purpose of the Study:

  • To investigate if water restriction combined with SB hydration induces renal damage.
  • To evaluate the role of vasopressin and oxidative stress in this process.
  • To compare the effects of water, SB, and stevia hydration under fluid restriction.

Main Methods:

  • Male Wistar rats were fluid restricted for 4 weeks.
  • Groups rehydrated with tap water (W), SB (11% fructose-glucose), or stevia (ST).
  • Renal damage markers, receptor expression, pathway activation, and oxidative stress were assessed.

Main Results:

  • Fluid restriction with water mildly increased urine osmolality and tubular damage markers (NAG, KIM-1).
  • SB hydration significantly amplified these changes, alongside V1a/V2 receptor overexpression, pathway activation, and oxidative stress.
  • Stevia hydration showed effects similar to water hydration.

Conclusions:

  • Current hydration habits, particularly SB consumption during fluid restriction, may be a risk factor for kidney damage.
  • SB intake exacerbates dehydration-induced renal alterations.
  • Stevia presents a potentially safer alternative to SB for hydration.