Age and gender dependence of liver diffusion parameters and the possibility that intravoxel incoherent motion...

The aim of this study was to establish reference values for middle-aged subjects and to investigate the age and gender dependence of liver diffusion MRI parameters. The IVIM type of liver diffusion scan was based on a single-shot spin-echo-type echo-planar sequence using a 1.5 T magnet with 16 b-values. Diffusion-derived vessel density (DDVD)(b0b2) or DDVD(b0b10) was the signal difference between b = 0 and b = 2 (or b = 10) s/mm² images after removing visible vessels. IVIM analysis was performed with full fitting and segmented fitting, and with a threshold b-value of 60 or 200 s/mm² , and fitting started from b = 2 s/mm² . Thirty-one men (age range: 25-71 years) and 26 men (age: 22-69 years) had DDVD and IVIM analysis, respectively, while 37 women (age: 20-71 years) and 36 women (age: 20-71 years) had DDVD and IVIM analysis, respectively. DDVD results showed a significant age-related reduction for women. IVIM results for full fitting showed excellent agreement with those for segmented fitting using a threshold b of 60 s/mm² , but this was less good for results with a threshold b of 200 s/mm² . As age increased, female subjects' D_slow measure showed a significant reduction, while their PF and D_fast measures showed a significant increase. For the age group of 40-55 years, DDVD(b0b2), DDVD(b0b10), D_slow , PF and D_fast were 12.26 ± 3.90 au/pixel, 16.95 ± 5.45 au/pixel, 1.072 ± 0.067 (10^-3 mm² /s), 0.141 ± 0.025 and 61.0 ± 14.0 (10^-3 mm² /s) for men, and 13.35 ± 3.6 au/pixel, 17.20 ± 3.62 au/pixel, 1.069 ± 0.074 (10^-3 mm² /s), 0.119 ± 0.014 and 57.1 ± 13.2 (10^-3 mm² /s) for women, respectively. DDVD measure of this study suggest that aging is associated with a reduction in liver perfusion. There is a possibility that a lower D_slow measure is associated with artificially higher PF and D_fast measures, and that IVIM modeling of the perfusion component is constrained by the diffusion component.