[Progress in researches on spontaneously mutated mouse model of male infertility]

Male infertility in animals are caused by many factors and mostly by genetic mutations. Spontaneously mutated mice have long been used as important animal models for basic medical researches on human genetic diseases and as valuable research tools for discovering new genes and their functions. Spontaneously mutated mice are often detected as random genetic events in zoos or research institutions that house large groups of mice, and they carry various phenotypes, some of which can cause male sterility. This review summarizes the types of spontaneously mutated mice carrying male infertility-related phenotypes to provide an animal model for the study of male infertility.