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Protective effect of Feijoa sellowianan fruit on testicular toxicity-induced by cadmium chloride
Elahe Horri1,2, Amir Esmaeilnejad Moghadam1, Fereshteh Talebpour Amiri1
1Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract:
The purpose of the present study was to investigate the protective potential of Feijoa fruit extract on cadmium chloride (CdCl2 )-induced testicular injury and pituitary-gonadal axis. Adult male Wistar rats were randomly divided into four groups: (a) control (normal saline, orally), (b) cadmium chloride (0.1 mg/kg, single dose, intraperitoneally), (c) Feijoa fruit extract (400 mg/kg, orally for 30 consecutive days) and (d) CdCl2 + Feijoa fruit extract. One day after receiving the last medicine, the LH, FSH, prolactin and testosterone concentration were assayed. Also, sperm parameters and tissue structure of the testis were evaluated. Administration of Feijoa fruit extract after CdCl2 injection in rats ameliorated sperm parameters such as sperm count, morphology, motility and sperm viability, increased levels of LH, FSH, prolactin and testosterone and improved testicular histology. According to the results of this study, it was shown that Feijoa can reduce the destructive side effects of CdCl2 on testicular tissue and sex hormones of the pituitary-gonadal pathway.
Insights
Feijoa fruit extract protects against cadmium chloride-induced testicular damage by improving sperm quality and restoring reproductive hormone levels. This study highlights Feijoa
Area of Science:
- Toxicology
- Reproductive Biology
- Phytochemistry
Background:
- Cadmium chloride (CdCl2) is a toxic heavy metal known to induce testicular injury.
- Disruption of the pituitary-gonadal axis and impaired reproductive function are significant concerns associated with cadmium exposure.
Purpose of the Study:
- To investigate the protective effects of Feijoa fruit extract against CdCl2-induced testicular damage.
- To evaluate the impact of Feijoa extract on the pituitary-gonadal axis and reproductive parameters in rats.
Main Methods:
- Adult male Wistar rats were exposed to CdCl2 and/or treated with Feijoa fruit extract.
- Hormone levels (LH, FSH, prolactin, testosterone), sperm parameters (count, morphology, motility, viability), and testicular histology were assessed.
Main Results:
- Feijoa fruit extract administration significantly ameliorated CdCl2-induced negative effects on sperm parameters.
- Treatment with Feijoa extract restored normal levels of LH, FSH, prolactin, and testosterone.
- Histological examination revealed improved testicular tissue structure in rats treated with Feijoa extract.
Conclusions:
- Feijoa fruit extract demonstrates significant protective potential against CdCl2-induced testicular toxicity.
- Feijoa extract can mitigate the adverse effects of cadmium on testicular tissue and the reproductive endocrine system.
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