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The relationship between lichen planus and metabolic syndrome
Munise Daye1, Selami Aykut Temiz2, Begüm Isık1
1Department of Dermatology, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey.
Journal of Cosmetic Dermatology
|December 28, 2020
Summary
Patients with lichen planus (LP) have a higher prevalence of metabolic syndrome (MS) compared to controls. This suggests increased metabolic complications in LP patients, particularly those with cutaneous disease activity.
Area of Science:
- Dermatology
- Internal Medicine
- Epidemiology
Background:
- Lichen planus (LP) is a chronic inflammatory condition with potential systemic implications.
- Metabolic syndrome (MS) comprises a cluster of conditions that increase the risk of heart disease, stroke, and diabetes.
- Limited research exists on the association between LP and MS.
Purpose of the Study:
- To investigate the relationship between metabolic syndrome (MS) and lichen planus (LP).
- To assess if disease activity in LP correlates with the presence of MS.
Main Methods:
- Retrospective analysis of 98 LP patients and 99 age- and sex-matched controls.
- Data collected from dermatology outpatient clinics between January 2018 and January 2020.
- Comparison of MS prevalence and correlation with disease severity between LP patients and controls.
Main Results:
- Metabolic syndrome (MS) was diagnosed in 48% of lichen planus (LP) patients, significantly higher than the 32.3% in the control group (P=.025).
- MS was observed in 60% of oral LP cases, though not statistically significant compared to controls (P=.29).
- A significant correlation was found between cutaneous LP disease severity and MS (P=.023), but not with oral LP severity (P=.19).
Conclusions:
- Lichen planus (LP) patients exhibit a higher prevalence of metabolic syndrome (MS).
- Metabolic complications should be considered during the management of LP patients.
- Particular attention is warranted for oral LP cases due to their association with MS.
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