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Related Concept Videos

Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Spermatogenesis01:41

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Spermatogenesis01:22

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Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
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Oogenesis02:07

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Nondisjunction01:29

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During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
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[on oligozoospermia and asthenospermia].

Mao-Lin Li1, Gui-Jie Wu1, Zhen-Huan Zhou1

  • 1Center of Reproductive Medicine, The Second Hospital of Jilin University， Changchun, Jilin 130022, China.

Zhonghua Nan Ke Xue = National Journal of Andrology
|December 28, 2020
PubMed
Summary

Yihechun Capsules (YHC) combined with Levocarnitine (LC) significantly improved sperm concentration and motility in infertile men. This combination therapy also led to a higher pregnancy rate compared to LC alone.

Keywords:
Yihechun Capsulesasthenospermiaclinical effectoligoasthenospermiaoligospermia

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Area of Science:

  • Reproductive Medicine
  • Andrology
  • Pharmacology

Background:

  • Oligozoospermia and asthenospermia are key contributors to male infertility.
  • Effective treatment options are crucial for improving reproductive outcomes.

Purpose of the Study:

  • To evaluate the clinical efficacy of Yihechun Capsules (YHC) in combination with Levocarnitine (LC) for treating oligozoospermia and asthenospermia.

Main Methods:

  • A randomized controlled trial involving 181 infertile males.
  • Patients were assigned to either YHC+LC or LC alone for 3 months.
  • Sperm concentration, motility (grade a and a+b), and pregnancy rates were assessed.

Main Results:

  • Both groups showed significant improvements in sperm parameters (P < 0.05).
  • The YHC+LC group demonstrated superior increases in sperm concentration and motility across all patient subgroups.
  • The YHC+LC group achieved a significantly higher pregnancy rate (36.4%) compared to the LC group (15.1%, P < 0.01).

Conclusions:

  • Yihechun Capsules combined with Levocarnitine is an effective treatment for oligozoospermia and asthenospermia.
  • This combination therapy offers a promising approach to enhance male fertility and pregnancy rates.