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Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research
Published on: March 29, 2024
Candida glabrata as an aetiological factor of the fulminant course of panophthalmitis
Joanna Bilska-Stokłosa1, Katarzyna Hampelska2, Krzysztof Osmola1
1Department of Maxillofacial Surgery, Heliodor Święcicki Clinical Hospital, University of Medical Sciences, Poznań, Poland.
Introduction:
The role of fungi in infections in immunocompromised patients is a growing problem in both diagnosis and treatment. Candida species are the most common cause of fungal, endogenous endophthalmitis and infections of the cornea.
Case Study:
A patient was admitted to hospital due to acute inflammation of the tissue of the left orbit, 1.5 years after the corneal penetrating transplantation of the left eye with intracapsular extraction of lens and simultaneous anterior vitrectomy. The microbiological system identified: Streptococcus pyogenes, Staphylococcus aureus, and Candida glabrata in the patient.
Conclusions:
The factors conducive to fungal infections are: patient's old age, immune disorders and diabetes, as well as the presence of a necrotic tissue or a foreign body. All these parameters were met in this case. Only antibiotic therapy and long-term antifungal therapy, together with surgical debridement of the site of the ongoing infection produces clinical effects in such severe cases.
Insights
Fungal infections, like Candida glabrata, pose a significant risk to immunocompromised patients, especially after eye surgery. Prompt antibiotic, antifungal therapy, and surgical debridement are crucial for managing severe orbital infections.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Fungal infections, particularly Candida species, present diagnostic and therapeutic challenges in immunocompromised individuals.
- Candida species are a leading cause of endogenous endophthalmitis and corneal infections.
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