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Updated: Nov 24, 2025

Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy
Published on: February 20, 2020
Use of Standard Addition to Quantify In Situ FTIR Reaction Data
George Hutchinson1, Calum D M Welsh2, Jordi Burés1
1Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
Abstract:
FTIR spectroscopy is a common in situ reaction monitoring technique used in modern academic and industrial environments. The FTIR signals collected during the course of a reaction are proportional to the concentration of the reaction components but not intrinsically quantitative. To make FTIR data quantitative, precalibration or offline analyses of reaction samples are required, which diminishes the unique benefits of in situ reaction monitoring techniques. Herein, we report the use of standard addition as a convenient method to obtain quantitative FTIR data.
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