The value of research on sexual dimorphism in neuroimaging

Spets and Slotnick (in Press) applied activation likelihood estimation meta-analysis to examine sex differences in regional brain activation during long-term memory retrieval. Based on their analyses, each of the eight studies they analyzed showed greater activity for males than females during long-term memory retrieval. These results suggest that analyses of magnetic resonance imaging data should not be collapsed by sex and expand this discussion to the challenge of meta-analysis on studies with small to modest sample sizes in favor of larger imaging studies with more rigorous thresholds.