Related Experiment Video
Updated: Nov 24, 2025
Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
Comparative Analysis of the MRI Characteristics of Meningiomas According to the 2016 WHO Pathological Classification
Juan Yu1,2, Fan-Fan Chen3, Han-Wen Zhang2
1Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Objects:
To evaluate the performance of preoperative magnetic resonance imaging (MRI) in evaluating diagnoses, operation methods and recurrence of meningiomas according to the World health organization (WHO) pathological classification.
Methods:
MRI characteristics of 127 meningioma patients were retrospectively analysed according to pathological results (WHO grade) and their association with Simpson's grades (resection) and recurrence.
Results:
The T1-weighted imaging (T1WI) signal intensity of WHO grade I meningiomas was slightly hypointense or isointense gray, while the T2-weighted imaging (T2WI) signal intensity was isointense or slightly hyperintense. The T1WI and T2WI signal intensity in WHO grade II and III meningiomas was isointense gray. The enhancement degree and patterns, lobulation, flowing voids, dural tail, maximum diameter, peritumoural oedema, ADC values and margin were significantly different between any 2 grades (P < 0.05). The ADC values were higher for WHO grade I tumors than for WHO grade II and III tumors (P < 0.001). Among all the analyzed characteriscs, ADC values, peritumoural oedema, and margin effectively predicted the diagnosis according to the WHO classification. The operation method and surgical resection were different between WHO grade Ⅰ and WHO grade Ⅱ/Ⅲ meningiomas (P < 0.05). The recurrence rate increased with tumor grade, but there was no statistical difference among the 3 types(P> 0.05).
Conclusions:
WHO grades and pathological subtypes of meningiomas can generally be determined based on their MRI characteristics. In addition, MRI provides significant guidance for the grading of surgical success and prognosis.
Insights
Magnetic resonance imaging (MRI) can predict meningioma World Health Organization (WHO) grades and subtypes. MRI findings also guide surgical success and prognosis, though recurrence rates did not significantly differ by grade.
Area of Science:
- Neurosurgery
- Radiology
- Oncology
Background:
- Meningiomas are the most common primary intracranial tumors.
- Accurate preoperative grading is crucial for treatment planning and prognosis.
- World Health Organization (WHO) pathological classification is standard for meningiomas.
Purpose of the Study:
- To assess the efficacy of preoperative magnetic resonance imaging (MRI) in determining meningioma diagnoses, guiding surgical approaches, and predicting recurrence based on WHO pathological classification.
- To correlate MRI characteristics with WHO grades, Simpson resection grades, and recurrence rates.
Main Methods:
- Retrospective analysis of MRI characteristics in 127 meningioma patients.
- Correlation of MRI findings (T1WI, T2WI signal intensity, enhancement, lobulation, ADC values, etc.) with WHO pathological grades.
- Comparison of MRI features across different WHO grades and their association with surgical outcomes and recurrence.
Main Results:
- Significant differences in enhancement patterns, lobulation, ADC values, and other features were observed between WHO grades (P < 0.05).
- ADC values were significantly higher in WHO grade I tumors compared to grades II and III (P < 0.001).
- MRI characteristics, particularly ADC values, peritumoral edema, and margin, effectively predicted WHO classification; recurrence rates increased with grade but lacked statistical significance.
Conclusions:
- Preoperative MRI characteristics can reliably predict WHO grades and pathological subtypes of meningiomas.
- MRI findings offer valuable guidance for assessing surgical success and patient prognosis.
