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Bing-Neel syndrome: A case reports
Sinan Demircioğlu1, Pembe Oltulu2, Ganime D Emlik3
1Department of Hematology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Introduction:
Bing-Neel syndrome (BNS) is a rare complication of of Waldenström macroglobulinemia (WM) identified by involvement of central nervous system (CNS) lymphoplasmacytic cells.
Case Report:
We present a patient who was diagnosed with Bing-Neel syndrome four years after the diagnosis of Waldenström macroglobulinemia.
Management & Outcome:
The patient was admitted with neurological symptoms. There were lesions associated with WM involvement on brain imaging. The diagnosis was made by brain biopsy. High dose methotrexate treatment was given.
Discussion:
CNS infiltrating agents such as fludarabine, methotrexate and cytarabine are often used in BNS treatment. Ibrutinib, which is a new bruton tyrosine kinase inhibitor, has recently started to be used in BNS treatment, as it has been shown to be effective and penetrate the CNS.
