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Viral Recombination

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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

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Complexity of host-vector dynamics in a two-strain dengue model.

Peter Rashkov¹, Bob W Kooi²

¹Institute of Mathematics and Informatics, Bulgarian Academy of Sciences, Sofia, Bulgaria.

Journal of Biological Dynamics

|December 28, 2020

Summary

This study models dengue fever with two strains, exploring how they interact and coexist in populations. The research simplifies complex disease dynamics to understand transmission patterns.

Keywords:

35B32 37N25 92D30 Dengue Vector-borne disease dynamics bifurcation analysis two-strain model

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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Area of Science:

Epidemiology
Mathematical Biology
Infectious Disease Dynamics

Background:

Dengue fever is a significant global health concern, transmitted by mosquitoes.
Understanding the dynamics of multiple dengue virus strains is crucial for effective control strategies.
Previous models often simplify host-vector interactions or strain competition.

Purpose of the Study:

To develop and analyze a compartmental host-vector model for dengue with two viral strains.
To investigate conditions for strain displacement or co-existence.
To explore the impact of temporary cross-immunity and secondary infections on disease dynamics.

Main Methods:

Utilized a slow-fast system approach to model host and vector epidemiological time scales.
Applied geometric singular perturbation techniques for model dimension reduction.
Conducted numerical bifurcation analysis using literature-derived parameter values.

Main Results:

Identified conditions for endemic equilibria where one dengue strain dominates or both co-exist.
Demonstrated the utility of quasi-steady state approximation for vector dynamics in simplifying the model.
Compared the bifurcation structure of the host-vector model with simpler host-only models.

Conclusions:

The host-vector model provides a more realistic framework for studying dengue transmission dynamics.
Dimension reduction techniques effectively capture essential disease dynamics.
The findings offer insights into the complex interplay of multiple dengue strains and host immunity.