Overweight, Obesity, and Late-Life Sarcopenia Among Men With Cardiovascular Disease, Israel

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Miri Lutski1,2, Galit Weinstein3, David Tanne4,5

  • 1The Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Israel.

Preventing Chronic Disease
|December 28, 2020
PubMed

Insights

Obesity is linked to a higher risk of sarcopenia, the age-related loss of muscle mass and function, in men with cardiovascular disease. This suggests obesity may be a modifiable factor to consider in preventing sarcopenia.

Area of Science:

  • Gerontology
  • Cardiology
  • Nutritional Science

Background:

  • Sarcopenia, the age-related loss of muscle mass and function, is a growing concern in aging populations.
  • The relationship between obesity and sarcopenia, particularly in individuals with cardiovascular disease, remains under-researched.

Purpose of the Study:

  • To investigate the association between overweight, obesity, and sarcopenia in community-dwelling men with cardiovascular disease.
  • To determine if obesity is a risk factor for developing sarcopenia in this specific patient group.

Main Methods:

  • A subset of 337 men from the Bezafibrate Infarction Prevention trial underwent sarcopenia evaluation.
  • A multinomial logistic model was used to analyze the odds of probable sarcopenia and sarcopenia based on body mass index (BMI).

Main Results:

  • Sarcopenia was prevalent in 54.3% of participants with obesity (BMI ≥30.0) and 37.0% of overweight participants (25.0 ≤ BMI ≤29.9).
  • Overweight and obesity (BMI ≥25.0) were associated with significantly higher odds of probable sarcopenia (OR=3.27) and sarcopenia (OR=5.31) compared to normal weight (BMI <25.0).

Conclusions:

  • A positive association exists between obesity and late-life sarcopenia in men with cardiovascular disease.
  • Obesity may be an important, modifiable risk factor for sarcopenia in this population.
Abstract

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