Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.0K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

14.4K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
14.4K
Inflammatory Response01:28

Inflammatory Response

15.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.1K
Inflammation01:38

Inflammation

57.9K
Overview
57.9K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.9K
Aging01:26

Aging

444
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
444

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Repeated Antigen Exposure on Humoral Tolerance: Antidrug Antibodies After Single-Dose Versus Multi-dose Adalimumab.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026
Same author

Dandruff Is a Low-Grade Inflammatory Condition Featuring Hyperproliferative Keratinocytes, Interleukin-17-Producing T Cells, and N-Acyl Ethanolamines.

Immunity, inflammation and disease·2026
Same author

Toward an understanding of neural responses to emotion in recent onset and chronic psoriasis: A feasibility brain imaging study.

JID innovations : skin science from molecules to population health·2026
Same author

Skin care without borders: A United Kingdom-Myanmar teledermatology initiative.

The Journal of investigative dermatology·2026
Same author

A survey of patients attending the Regional Dermatology Training Centre, Moshi, Tanzania, 2017-2020.

The Journal of investigative dermatology·2026
Same author

Evaluation of a Therapeutic Drug Monitoring Strategy for Adalimumab in Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study.

Clinical and translational science·2026
Same journal

Introducing lesion-level metrics for melanocytic neoplasm clustering: Practical tools with potential applications in clinical practice.

The Journal of investigative dermatology·2026
Same journal

Reducing plastic waste in skin-model research: Sustainable packaging as a practical first step.

The Journal of investigative dermatology·2026
Same journal

Modern serum proteomics in precision medicine: Toward disease stratification and predictive, proactive treatment strategies.

The Journal of investigative dermatology·2026
Same journal

An Integrated Skin Cell Atlas Decodes the Pilosebaceous Unit.

The Journal of investigative dermatology·2026
Same journal

Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

The Journal of investigative dermatology·2026
Same journal

Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

The Journal of investigative dermatology·2026
See all related articles

Related Experiment Video

Updated: Nov 24, 2025

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

8.0K

Inflammaging and the Skin.

Suzanne M Pilkington1, Silvia Bulfone-Paus2, Christopher E M Griffiths3

  • 1Centre for Dermatology Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Lydia Becker Institute of Immunology and Inflammation, The University of Manchester, Manchester, United Kingdom; Manchester Institute for Collaborative Research on Aging, The University of Manchester, Manchester, United Kingdom.

The Journal of Investigative Dermatology
|December 28, 2020
PubMed
Summary
This summary is machine-generated.

Inflammaging, chronic inflammation linked to aging, impacts skin health. This review explores inflammaging

More Related Videos

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
09:01

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay

Published on: December 30, 2014

9.9K
Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

1.9K

Related Experiment Videos

Last Updated: Nov 24, 2025

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

8.0K
Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
09:01

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay

Published on: December 30, 2014

9.9K
Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

1.9K

Area of Science:

  • Gerontology and Dermatology
  • Immunology of Aging
  • Cellular Biology

Background:

  • Global life expectancy is increasing, necessitating strategies for healthy aging.
  • Chronic low-level inflammation, termed inflammaging, is a hallmark of aging.
  • Inflammaging is associated with age-related diseases and functional decline in organs.

Purpose of the Study:

  • To review the evidence for inflammaging in the skin.
  • To examine the relationship between skin inflammaging and cellular senescence.
  • To understand how inflammaging contributes to age-related skin structure and function decline.

Main Methods:

  • Literature review of studies on skin aging and inflammation.
  • Analysis of research linking inflammaging markers to skin senescence.
  • Synthesis of data on the impact of inflammaging on skin physiology.

Main Results:

  • Evidence suggests inflammaging occurs in aged skin.
  • Cellular senescence is closely linked to inflammaging processes in the skin.
  • Inflammaging contributes to the structural and functional deterioration of aging skin.

Conclusions:

  • Inflammaging is a significant factor in skin aging.
  • Targeting inflammaging may offer strategies to improve skin health in older adults.
  • Further research is needed to fully elucidate the mechanisms and therapeutic potential.