Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Carina Behrends1, Jan Haussmann2, P-H Kramer3

  • 1West German Proton Therapy Centre Essen (WPE), Essen, Germany; Heinrich-Heine-University, Düsseldorf, Germany; West German Cancer Centre (WTZ), Essen, Germany.

Zeitschrift Fur Medizinische Physik
|December 28, 2020
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guidance for the Diagnosis and Treatment of Rare Embryonal and Sarcomatous Brain Tumors-a Report from the Central Nervous System-International Registry for Rare Embryonal and Sarcomatous Tumors German Society of Pediatric Oncology and Hematology Study Group.

Klinische Padiatrie·2026
Same author

Treatment effect heterogeneity of radiotherapy in localized Ewing sarcoma: A secondary analysis of the EURO-E.W.I.N.G. 99 and Ewing 2008 trial.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Deep learning for dose-averaged linear energy transfer estimation in pencil-beam scanning and double scattering proton radiotherapy plans with uncertainty-aware external validation.

Physics and imaging in radiation oncology·2026
Same author

ESTRO clinical practice guideline on radiotherapy for adult soft tissue sarcoma of the extremities and trunk wall - Endorsed by ASTRO.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Radiation-induced oral side effects in head and neck cancer: a scoping review and interdisciplinary recommendations.

BMC oral health·2026
Same author

The HIT Network for Children and Adolescents With CNS Tumors Facilitates Improvements of Diagnostic Assessments, Multimodal Treatments, Individual Counseling, and Research in Germany, Austria, and Switzerland.

Pediatric blood & cancer·2026
Same journal

Determination of long-range resistance from high resolution impedance spectroscopy in human cadaveric heads.

Zeitschrift fur medizinische Physik·2026
Same journal

Patient-specific quality assurance in stereotactic radiotherapy: clinical practice in absence of guidelines - status and new approach from the DGMP working group for physics and technology in stereotactic radiotherapy.

Zeitschrift fur medizinische Physik·2026
Same journal

Potential and challenges of Positron Emission Tomography beyond conventional preclinical and clinical imaging.

Zeitschrift fur medizinische Physik·2026
Same journal

Evaluation of PET/CT Artificial Intelligence Image Reconstructions VS Harmonized Clinical Reconstruction.

Zeitschrift fur medizinische Physik·2026
Same journal

Adaptation of quality control pipeline for Skeletal Muscle 31P MR Spectroscopy at 3T and 7T.

Zeitschrift fur medizinische Physik·2026
Same journal

Complexity metrics for Tomotherapy: application to the verification of transferred plans.

Zeitschrift fur medizinische Physik·2026
See all related articles
This summary is machine-generated.

Intensity-modulated proton therapy (IMPT) offers improved protection for organs at risk compared to VMAT, potentially benefiting about one-third of head and neck cancer patients by reducing late side effects and enhancing quality of life.

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Clinical Outcomes Research

Background:

  • Comparing intensity-modulated proton therapy (IMPT) and volume-modulated arc therapy (VMAT) is crucial for selecting optimal radiation modalities.
  • Normal tissue complication probability (NTCP) models aid in evaluating the clinical benefits of different radiation techniques.

Purpose of the Study:

  • To compare IMPT and VMAT treatment plans for head and neck tumors using NTCP models.
  • To assess the impact of IMPT on patient quality of life (QoL) by evaluating potential late side effects.

Main Methods:

  • Robustly optimized IMPT plans were created for 50 patients previously treated with photon therapy.
  • Monte Carlo (MC) algorithms calculated dose distributions.
  • Dose-volume parameters for organs at risk (OARs) and NTCP calculations (xerostomia, sticky saliva, dysphagia, tube feeding) were performed using Langendijk's model.
Keywords:
Head and neck cancerNTCP-modelsPhoton therapyProton therapy

Related Experiment Videos

Main Results:

  • IMPT plans demonstrated similar target volume dose distribution but superior OAR protection compared to VMAT.
  • The primary advantage of protons lies in reducing mid-to-low dose levels, not just high-dose confirmation.
  • Approximately one-third of patients showed significant potential benefit from proton therapy regarding late side effects.

Conclusions:

  • IMPT offers significant advantages over VMAT in protecting OARs for head and neck cancer patients.
  • Proton therapy's benefits are linked to reduced low-to-mid dose bath, potentially improving patient QoL and reducing late toxicities.
  • Further clinical data is necessary to validate these model-based findings.