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Related Concept Videos

Oogenesis02:07

Oogenesis

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Meiosis vs. Mitosis02:57

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Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
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Nondisjunction01:21

Nondisjunction

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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Preconception tests at advanced maternal age.

Elpiniki Chronopoulou1, Claudia Raperport1, Paul Serhal2

  • 1Homerton Fertility Centre, Homerton University Hospital, Homerton Row, Clapton, London, E9 6SR, UK.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|December 28, 2020
PubMed
Summary
This summary is machine-generated.

Advanced maternal age pregnancies require tailored preconception testing. Early identification and management of risks optimize maternal health and reduce pregnancy complications.

Keywords:
Advanced maternal ageLifestyle: perinatal outcomesPreconception

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Area of Science:

  • Reproductive Medicine
  • Maternal-Fetal Medicine
  • Public Health

Background:

  • Advanced reproductive age pregnancies are rising globally.
  • Maternal age is an independent risk factor for obstetric complications and pre-existing health conditions.
  • Current preconception guidance lacks specific recommendations for advanced maternal age.

Purpose of the Study:

  • To highlight the need for structured preconception testing for women of advanced reproductive age.
  • To emphasize the critical window of the preconceptual period for optimizing maternal health.
  • To underscore the potential of preconception care in mitigating infertility and perinatal morbidity/mortality.

Main Methods:

  • This is a conceptual paper based on existing literature and clinical knowledge.
  • It reviews the risks associated with advanced maternal age.
  • It advocates for clinically relevant preconception tests tailored to identify and manage risk factors.

Main Results:

  • Advanced maternal age is associated with increased risks of infertility and pregnancy complications.
  • Preconception care offers a vital opportunity to address health and lifestyle factors.
  • Targeted preconception tests can predict and prevent adverse outcomes.

Conclusions:

  • Structured preconception testing is crucial for women of advanced reproductive age.
  • Optimizing maternal health before conception can significantly reduce perinatal morbidity and mortality.
  • Personalized preconception care is essential for improving pregnancy outcomes in older women.