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Targeting CTGF in Cancer: An Emerging Therapeutic Opportunity

Yi-Wen Shen1, Yu-Dong Zhou2, Hong-Zhuan Chen1

  • 1Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Trends in Cancer
|December 28, 2020
PubMed

Insights

Connective tissue growth factor (CTGF) drives cancer growth, spread, and drug resistance. Targeting CTGF offers a promising strategy to improve cancer patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Despite advances, effective cancer therapies remain critical.
  • Connective tissue growth factor (CTGF) is implicated in cancer initiation, progression, and metastasis.
  • CTGF influences tumor microenvironment factors like angiogenesis and inflammation.

Purpose of the Study:

  • To comprehensively review the role of CTGF in cancer.
  • To discuss CTGF's expression, regulation, and oncogenic functions.
  • To explore clinical relevance, targeting strategies, and therapeutic agents for CTGF.

Main Methods:

  • Literature review of scientific publications on CTGF and cancer.
  • Analysis of CTGF's involvement in cellular processes (proliferation, migration, invasion, EMT).
  • Examination of CTGF's role in the tumor microenvironment (angiogenesis, inflammation, CAF activation).

Main Results:

  • CTGF promotes cancer cell proliferation, migration, invasion, and drug resistance.
  • CTGF regulates epithelial-mesenchymal transition (EMT), aiding metastasis.
  • CTGF is integral to the tumor microenvironment, supporting tumor growth and progression.

Conclusions:

  • CTGF is a significant driver of multiple aspects of cancer.
  • Targeting CTGF presents a promising therapeutic avenue.
  • Modulating CTGF could lead to improved clinical outcomes for cancer patients.
Keywords:
CTGF/CCN2cancercellular functionconnective tissue growth factortargeted therapytumor microenvironment

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