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Related Experiment Video

Updated: Nov 24, 2025

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

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Aberrant Cortical Connectivity During Ambiguous Object Recognition Is Associated With Schizophrenia.

Victor J Pokorny¹, Tori D Espensen-Sturges², Philip C Burton³

¹Minneapolis Veterans Affairs Health Care System, University of Minnesota, Minneapolis, Minnesota.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging

|December 28, 2020

Summary

Schizophrenia (SCZ) involves inefficient visual object processing due to disrupted neural connectivity. This study examined brain connectivity in SCZ, bipolar disorder, and relatives, revealing distinct aberrant patterns in visual processing areas.

Keywords:

Object recognition Psychosis Schizophrenia Vision fMRI

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Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

Dysfunctional connectivity in the perceptual hierarchy is a key aspect of psychosis.
Investigating neural connectivity during object recognition is crucial for understanding schizophrenia (SCZ).

Purpose of the Study:

To investigate neural connectivity during object recognition in patients with schizophrenia (SCZ), bipolar disorder, and their relatives (SREL).
To explore the role of dysfunctional connectivity in the perceptual hierarchy within psychosis.

Main Methods:

Functional magnetic resonance imaging (fMRI) data from 27 SCZ patients, 23 bipolar disorder patients, 24 controls, and 19 SREL were analyzed.
The fragmented ambiguous object task was used to assess neural responses to visual stimuli.
Region of interest analyses focused on primary visual cortex (V1), lateral occipital complex, intraparietal sulcus (IPS), and middle frontal gyrus (MFG).

Main Results:

Schizophrenia (SCZ) showed altered neural activations in V1, IPS, and MFG.
Negative connectivity between V1 and MFG was observed in patient groups.
Altered connectivity modulation from right IPS to left IPS and MFG was found in SCZ and SREL patients.

Conclusions:

Schizophrenia (SCZ) is linked to inefficient processing of ambiguous visual objects, possibly due to altered feedback from higher visual areas.
Distinct patterns of aberrant connectivity were observed across low-level, mid-level, and high-level visual areas in patients with SCZ, bipolar disorder, and SREL.