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Investigating the effects of the core nitrogen atom configuration on the thermodynamic solubility of 6,5-bicyclic

Brett Cosgrove1, Kenneth Down2, Sophie Bertrand2

  • 1Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, UK; Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK.

Bioorganic & Medicinal Chemistry Letters
|December 28, 2020
PubMed

Keywords:
ChromlogD(7.4)Fasted State Simulated Intestinal fluid (FaSSIF)General Solubility Equation (GSE)Kinetic solubilityPhysicochemical propertiesSimulated lung fluid (SLF)Thermodynamic solubility

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